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KMID : 0043320080310081050
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Archives of Pharmacal Research
2008 Volume.31 No. 8 p.1050 ~ p.1054
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The Intracellular Uptake Ability of Chitosan-coated Poly (D,L-lactideco-glycolide) Nanoparticles
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Kim Beom-Su
Kim Cheol-Sang
Lee Kang-Min
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Abstract
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In this study, we prepared chitosan-coated Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles. Specifically, we utilized a double emulsion-solvent evaporation technique to formulate nanoparticles containing paclitaxel as a model macromolecule and 6-coumarin as a fluorescent marker. SEM images verified that all nanoparticles were spherical in shape with smooth surfaces. Chitosan coating slightly increased the size distribution of the PLGA/PVA nanoparticles, from to , but the encapsulation efficiency was not significantly different. In contrast, coating with chitosan slowed the in vitro drug release rate and significantly changed the zeta potential from negative () to positive (). At the initial burst time, the drug release rate from chitosancoated nanoparticles was slightly slower than that of the uncoated nanoparticles. Chitosan-coated nanoparticles were also taken up much more efficiently than uncoated nanoparticles. This study demonstrated the efficacy of chitosancoated PLGA nanoparticles as an efficient delivery system.
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KEYWORD
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Chitosan, Nanoparticle, Poly(D, L-lactic-co-glycolide), Intracellular, Drug delivery, Zeta potential, Paclitaxel
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